{"id":14401,"date":"2024-02-12T12:38:04","date_gmt":"2024-02-12T12:38:04","guid":{"rendered":"http:\/\/TheNextWeb=1403783"},"modified":"2024-02-12T12:38:04","modified_gmt":"2024-02-12T12:38:04","slug":"new-biotech-startup-targets-genes-to-treat-skin-diseases","status":"publish","type":"post","link":"https:\/\/www.londonchiropracter.com\/?p=14401","title":{"rendered":"New biotech startup targets genes to treat skin diseases"},"content":{"rendered":"\n<div><img decoding=\"async\" src=\"https:\/\/img-cdn.tnwcdn.com\/image\/tnw-blurple?filter_last=1&amp;fit=1280%2C640&amp;url=https%3A%2F%2Fcdn0.tnwcdn.com%2Fwp-content%2Fblogs.dir%2F1%2Ffiles%2F2024%2F02%2FUntitled-design-26-4.jpg&amp;signature=05a2b7d5770b16b1280578dc982a7661\" class=\"ff-og-image-inserted\"><\/div>\n<p>A new biotech startup developing immuno-dermatology technologies for skin diseases has launched today with $100mn (\u20ac93mn) in seed <a href=\"https:\/\/thenextweb.com\/topic\/funding\" target=\"_blank\" rel=\"noopener\">funding<\/a>.<\/p>\n<p>Based in Boston and Geneva, Alys Pharmaceuticals is co-founded by Medicixi, a European healthcare-focused investment firm, and six university scientists, including Nobel Prize winner Craig Mello.<\/p>\n<p>The <a href=\"https:\/\/thenextweb.com\/topic\/funding\" target=\"_blank\" rel=\"noopener\">startup<\/a> is a merger of six individual companies in the field (also backed by Medicixi), which in combination boast 14 active R&amp;D programmes.<\/p>\n<p>Alys is targeting chronic autoimmune skin conditions, including atopic dermatitis (eczema), alopecia areata (loss of hair), vitiligo (discoloration of the skin), and spontaneous urticaria (hives). For context, <a href=\"https:\/\/nationaleczema.org\/research\/eczema-facts\/\" target=\"_blank\" rel=\"nofollow noopener\">1 in 10<\/a> individuals will develop eczema during their lifetime, while <a href=\"https:\/\/globalvitiligofoundation.org\/vitiligo-facts\/\" target=\"_blank\" rel=\"nofollow noopener\">1%<\/a> of the population suffers from vitiligo.<\/p>\n<div class=\"inarticle-wrapper channel-cta\">\n<div class=\"ica-text\" readability=\"0\"><a href=\"https:\/\/thenextweb.com\/conference\/tickets?utm_source=TNW-media&amp;utm_medium=display&amp;utm_campaign=TNW2024flashsale\" data-event-category=\"Article\" data-event-action=\"In Article Block\" data-event-label=\"TNW Conference 2024 - 2 for 1 Flash Sale\" target=\"_blank\" readability=\"4\" rel=\"noopener\"><\/p>\n<p class=\"ica-text__title\">TNW Conference 2024 &#8211; 2 for 1 Flash Sale<\/p>\n<p>Get two tickets for the price of one. Offer Ends on Monday 12 February<\/p>\n<p><\/a><\/div>\n<\/div>\n<p>As these diseases are (currently) incurable, effective treatment plays a vital role both in the <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/ijd.14763\" target=\"_blank\" rel=\"nofollow noopener\">quality of life<\/a> and <a href=\"https:\/\/jamanetwork.com\/journals\/jamadermatology\/fullarticle\/2808976#:~:text=Patients%20with%20vitiligo%20are%20also,without%20vitiligo%20serving%20as%20controls.&amp;text=Psychosocial%20stressors%20are%20associated%20with%20vitiligo%20onset%20or%20flares.&amp;text=There%20is%20a%20need%20to,vitiligo%20from%20the%20patient%20perspective.\" target=\"_blank\" rel=\"nofollow noopener\">psychology<\/a> of the patients.<\/p>\n<p>Beyond the above conditions, Alys\u2019s pipeline also focuses on mastocytosis (abnormal accumulation of mast cells in the body), cutaneous T-cell lymphoma (a rare type of cancer), and the prevention of skin side effects of oncology therapies.<\/p>\n<p>To further advance treatments, the startup is working on \u201cbreakthrough\u201d technologies such as peptides (short chains of amino acids), sophisticated antibodies, and vectorised siRNA (short interference RNA), which aims to \u201csilence\u201d the genes responsible for unwanted behaviour.<\/p>\n<p>According to Thibaud Portal, Aly\u2019s COO, the company doesn\u2019t target a share of existing markets. \u201cNew dermatology products will grow the market,\u201d he <a href=\"https:\/\/www.ft.com\/content\/a076888e-f6af-4a1b-8244-11a13daab778\" target=\"_blank\" rel=\"nofollow noopener\">told<\/a> the Financial Times. \u201cWe can address the huge number of patients who are currently without treatment.\u201d<\/p>\n<p>Over the next three years, the startup aims to deliver proof-of-concept results for seven to ten skin treatments.<\/p>\n<p> <a href=\"https:\/\/thenextweb.com\/news\/biotech-startup-targets-genes-treat-skin-diseases\">Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new biotech startup developing immuno-dermatology technologies for skin diseases has launched today with $100mn (\u20ac93mn) in seed funding. Based in Boston and Geneva, Alys Pharmaceuticals is co-founded by Medicixi, a European&#8230;<\/p>\n","protected":false},"author":1,"featured_media":14402,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=\/wp\/v2\/posts\/14401"}],"collection":[{"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14401"}],"version-history":[{"count":0,"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=\/wp\/v2\/posts\/14401\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=\/wp\/v2\/media\/14402"}],"wp:attachment":[{"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=14401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.londonchiropracter.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=14401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}